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lorlatinib will lessen the extent or influence of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Stay clear of use of lorlatinib with CYP3A substrates, where by minimum focus modifications may perhaps produce severe therapeutic failures with the substrate.

Ergotism manifested by intensive arterial vasoconstriction, making signs and signs and symptoms of peripheral vascular ischemia

turmeric will boost the amount or outcome of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.

atazanavir will improve the amount or result of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.

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enasidenib will decrease the extent or outcome of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. Enasidenib (a weak CYP3A4 inducer) might minimize systemic publicity of CYP3A4 substrates. Check and alter dose of substrate as clinically indicated.

caffeine increases toxicity of bupropion by unspecified interaction system. Avoid or Use Alternate Drug. May perhaps decreased seizure threshold; maintain bupropion dose as very low as you possibly can.

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cyclophosphamide will raise the degree or result of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unknown.

On initiation or discontinuation of guselkumab in individuals who will be receiving concomitant CYP450 substrates, significantly those by using a slender therapeutic index, take into account checking for therapeutic effect.

Ergotamine is excreted in breast milk and may trigger signs or symptoms of vomiting, diarrhea, weak pulse, and unstable hypertension in nursing infants

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mobocertinib will lower the level or result of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. If use is unavoidable, maximize CYP3A4 substrate dosage in accordance with its prescribing facts.

isavuconazonium sulfate will boost the level or influence of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.